Second chances
After getting my millionth Milabrega's Orb from Mephisto, I decided to do a Pindle run. Lo and behold, as my enemy lay vanquished on the mountainside he coughed up a godly sword: Doombringer! For a barbarian who prefers total melee, this was a godsend. Sadly, I was dual wielding at the time and was unfortunately locked into position. Not realizing that all I had to do was to perform a weapon switch (thus negating my freeze-up), I had to restart my game WITHOUT PICKING UP DOOMBRINGER!
My next Pindle run didn't yield anything special but the one after that, if you can believe it, there was Doombringer again (what are the odds?!?) This time, I picked it up and never looked back.