The title is kinda generic so let me rephrase it a bit. Would you play a specific build without a specific runeword/unique/set? There are many builds that are generally very strong or entertaining but without certain equip (let's face it, it's Enigma for the biggest part) are either just decent or can even be seriously annyoing to play. Easiest examples to come out of mind are enigma-less Hammerdin and Windy druid. Those builds simply need their positioning to be just right to be efficient that playing them without teleport is really an annoyance at a times. Are there any builds like that for you? And what item is stopping you from playing it?