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What’s best for the 4th item in griz Caduceus?

What’s best for the 4th item in griz Caduceus?
I’m making a pvp rabies/fury werewolf, so after 3 sheals what’s best for the 4th sockets?
I’ve seen LO runes and UM, but how about, CHAM or BER?

Also can glves spawn w/ +2 or +3 to shape skills?
I've never seen any, but would do more dmg than trangs.
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