I haven't maxed my synergies yet and I've got DWeb/Triple Trang's, but I sure wouldn't mind having a good Bramble to help kill a lot of the tougher baddies in Act 4 + 5 in Hell and you can always afford to kill bosses faster. 40-50% damage added to your attack AFTER synergies is nothing to scoff at. I'm also playing a Poiskellomancer variant so having the thorns/spirit auras on top of the nova and amped damage attacks would make for some nice gravy. I'm looking forward to getting my first Enigma sometime, but first I'd like to try a Bramble out.