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poison reduction rules

Hey, I would like to think I know the typical gm rules concerning sorb and stack and whatnot, but Ive never seen gm rules concerning poison reduction. So Id like to hear personal and/or universal rules you all know of concerning this.

NOTE: I don't want this to turn into one of those flaming spam fests about gm/bm, just your personal outlook on poison reduction or any universal rules you know about this.
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