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Need some help understanding itemization

I'm new to D2, and I was reading over the 1-pt smiter guide to Uber Tristram (http://diablo.incgamers.com/forums/showthread.php?t=425449). I know that I'll probably never see a lot of the gear that the guide lists, but I'm curious as to how you set it all up.

For example, the guide says the best weapon would be a Grief phase blade. Would I just have to be on the look out for a phase blade with 5 sockets, or should I find a superior phase blade and use the socket quest reward on it? I think a phase blade can have up to 6 sockets, but can you game the item level so the quest gives you a superior phase blade with 5 sockets? What would be the best possible phase blade to put Grief into, and how much does it matter? And after all of that, you have to hope you get good rolls on the Grief stats, right?

Similarly, how does it work for the Sanctuary shield and Fortitude armor? Try to find the best possible Chromatic Sacred Targe and hope for the best Sanctuary roll? Is Archon Plate the best thing to put Fortitude into since it's light armor?

I guess all of these questions basically boil down into: How do you know the right item to put a runeword into?

Thanks for any guidance.
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