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How does -enemy def work with -% enemy def?

I asked this in the Zon forum, because I'm making a Zon with Fleshripper (-50% Target Defense) and I wanted to know if maxing Inner Sight was a good idea, but nobody there knew how the two would mix.

In retrospect, this was the right place to ask.

So...Fleshripper has -50% Target Defense and level 23 Inner Sight gives -1015 Target Defense. How do they work together? And are the monster defense values listed on the Arreat Summit accurate?
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