Re: Hotkeys/skills
Left click on the skill icon in the status bar at the bottom of the screen. Now, hover over the skill you want to be used with F1, then press F1. That should bind F1 to that skill.
But, as Mursilis said, you don't have to use the function keys. I use
qwer
asdf
zxcv
And I set the character screen to Y and the quest screen to U. This is helpful if you have any characters with lots of skills (most of mine do). Then, Q is always teleport (on sorcs anyway) and R is always townportal.