Feline health question I have an 18 year-old female calico who suffers from chronic urinary tract infections. The three most recent infections have been multi-drug resistant E-coli bacteria (presumably originating from her own digestive tract). A previous hypothyroid condition has been successfully treated. She is also (like most cats her age) in declining kidney health, though not yet in renal failure. I treat her with subcutaneous fluids more than twice per week, yet she suffers from constipation when not on antibiotics (which cause diarrhea) â€“ for which I give her a stool softener. I also daily clean her orifices with antibacterial wipes in the hopes of avoiding infections, but to no avail. The last three times, she has re-developed an infection within two week of the conclusion of a course of antibiotics (6-8 weeks in duration, prescribed based on sensitivity tests with cultures). Her veterinarians have suggested the possibility of surgery to reduce the folds of skin around her vagina, to reduce the accumulation of bacterial-bearing feces, but her age and the fact that I clean her daily argues against this route, and none of the vets are actively pushing it. I have thoroughly read feline-care forums for suggestions, but to no avail, so I post here only as a last-gasp effort in the hopes that someone has had a similar experience. Two years ago I had to have her 'brother' (unrelated, but adopted at the same time) put to sleep due to renal failure. I subsequently feel I waited too long, and donâ€™t want Samantha to suffer, but hope that her quality of life is not too bad despite all the treatments and vet visits she has to go through.