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Any PvM builds for this weapon?

I just found a near perfect(238%) Cranium Basher on HCLadder while doing a pit run wiht my trapper. Was wondering what build it might be suitable for, if any... :/
My only charachter right now is my assassin and basically I have been trying to wait as long as possible to start a new charachter until I find a good weapon that is sorta "end of the line" so to speak. And Basher seems to me at least to be a good weapon, perhaps not close to runeword quality but maybe decent still?
The next char I will make must be one that is able to take out the Dclone and of course fun to play. I had been thinking abit of making a zealot or barb ww:er which obviously this weapon dont work well on. But what build does? Could a werebear mauler for example make use of Cranium Basher, would the speed be enough with shael rune and highlords,20ias gloves etc? And is the chance to cast amp a decent way to enable soling, i mean the ability to remove physical immunities? Any other build perhaps? Berserk barb? (2hand in hardcore zero def :p shows balls at least)
Here is the stats by the way for the weapon if anyone dont remember the mods:

Two-Hand Damage: (119-132) To (560-632) (339.5-382 Avg)
Required Level: 87
Required Strength: 253
Base Weapon Speed: [20]
+200-240% Enhanced Damage (varies) [mine is 238%]
+20 To Minimum Damage
+50% Damage To Undead
75% Chance Of Crushing Blow
4% Chance To Cast Level 1 Amplify Damage On Striking
20% Increased Attack Speed
All Resistances +25
+25 To Strength
+20 To Maximum Damage (not shown)
Indestructible

Hope someone have an idea, I'm beginning to feel like I REALLY NEED to get my butt of the wagon and start a new char very soon....
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