Bashiok posted an interesting tidbit about how big chests might be handled in Diablo III. No, this has nothing to do with the Amazon returning.
There have been a few discussions about chests, what they meant in the previous game, and what they’ll mean in Diablo III. Currently there are no locked chests, and it’s not something we’re looking to reintroduce for now. We have discussed varying chest quality and types, adding randomness not only to the appearance of a chest but also the value of items it may drop or possibly specifically what types of items it’s guaranteed to drop. Mix it up a bit and make finding a chest exciting, but make finding a special chest something even rarer and more exciting. It could certainly make exploring the entire floor of a dungeon more compelling before moving on.
Will anyone miss locked chests? Most players found them to be fairly pointless and occasionally annoying in Diablo II, since they forced you to waste an inventory spot on keys, and yet didn’t necessarily have any more loot than a regular chest.